Brian S. Blagg: search on Z-Library

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1

Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?

Khandelwal, Anuj, Crowley, Vincent M., Blagg, Brian S. J.

Journal:

Medicinal Research Reviews

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

2

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

Neckers, Len, Blagg, Brian, Haystead, Timothy, Trepel, Jane B., Whitesell, Luke, Picard, Didier

Journal:

Cell Stress and Chaperones

Year:

2018

Language:

english

File:

PDF, 1.36 MB

english, 2018

3

Synthesis and evaluation of electron-rich curcumin analogues

Michael W. Amolins, Laura B. Peterson, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 609 KB

english, 2009

4

Gambogic Acid, a Natural Product Inhibitor of Hsp90

Davenport, Jason, Manjarrez, Jacob R., Peterson, Laura, Krumm, Brian, Blagg, Brian S. J., Matts, Robert L.

Journal:

Journal of Natural Products

Year:

2011

Language:

english

File:

PDF, 1.90 MB

english, 2011

5

High-throughput screening for Hsp90 ATPase inhibitors

Christopher Avila, M. Kyle Hadden, Zeqiang Ma, Boris A. Kornilayev, Qi-Zhuang Ye, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 228 KB

english, 2006

6

Syntheses of photolabile novobiocin analogues

Gang Shen, Xiao ming Yu, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

7

A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity

Sabah Ansar, Joseph A. Burlison, M. Kyle Hadden, Xiao Ming Yu, Kelly E. Desino, Jennifer Bean, Len Neckers, Ken L. Audus, Mary L. Michaelis, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

8

52. A Novel Small Molecule HSP90 Inhibitor With Antiproliferative Effects in Differentiated and Anaplastic Thyroid Cancers

Brian Hirsch, Melanie Rohr, Brianne Patton, Brian Blagg, William R. Herre, Mark S. Cohen

Journal:

Journal of Surgical Research

Year:

2008

Language:

english

File:

PDF, 49 KB

english, 2008

9

Synthesis and Evaluation of Radamide Analogues, A Chimera of Radicicol and Geldanamycin

Hadden, M. Kyle, Blagg, Brian S. J.

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 1.80 MB

english, 2009

10

P2-384: In vivo effects of novel Hsp90 C-terminal inhibitors in Tau mutant mice

Michaelis, Mary L., Ansar, Sabah, Chigurupati, Radha, Menchen, Heather, Blagg, Brian, Rajewski, Roger

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

11

Hsp90: A Novel Target for the Disruption of Multiple Signaling Cascades

Bishop, Stephanie, Burlison, Joseph, J. Blagg, Brian

Journal:

Current Cancer Drug Targets

Year:

2007

Language:

english

File:

PDF, 276 KB

english, 2007

12

A novel heat shock protein 90 inhibitor potently targets adrenocortical carcinoma tumor suppression

Wang, Ton, Subramanian, Chitra, Blagg, Brian S.J., Cohen, Mark S.

Journal:

Year:

2019

File:

PDF, 1.79 MB

2019

13

The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies

Chaudhury, Subhabrata, Keegan, Bradley M., Blagg, Brian S. J.

Journal:

Medicinal Research Reviews

Year:

2020

File:

PDF, 1.53 MB

2020

14

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

TomaÅ¡iÄ, Tihomir, Durcik, Martina, Keegan, Bradley M., Skledar, Darja Gramec, Zajec, Å½iva, Blagg, Brian S. J., Bryant, Sharon D.

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 7.84 MB

2020

15

Design, Synthesis, and Evaluation of a Radicicol and Geldanamycin Chimera, Radamide.

Randell C. Clevenger, Brian S. J. Blagg

Journal:

Year:

2005

File:

PDF, 10 KB

2005

16

Uptake, Distribution and Diffusivity of Reactive Fluorophores in Cells: Implications toward Target Identification

Cunningham, Christopher W., Mukhopadhyay, Archana, Lushington, Gerald H., Blagg, Brian S. J., Prisinzano, Thomas E., Krise, Jeffrey P.

Journal:

Molecular Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 4.98 MB

english, 2010

17

Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors

Byrd, Katherine M., Subramanian, Chitra, Sanchez, Jacqueline, Motiwala, Hashim F., Liu, Weiya, Cohen, Mark S., Holzbeierlein, Jeffrey, Blagg, Brian S. J.

Journal:

Chemistry - A European Journal

Year:

2016

Language:

english

File:

PDF, 1.65 MB

english, 2016

18

Second Generation Grp94-selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer

crowley, vincent, huard, Dustin, lieberman, raquel, Blagg, Brian

Journal:

Chemistry - A European Journal

Year:

2017

Language:

english

File:

PDF, 1.73 MB

english, 2017

19

Development and optimization of a useful assay for determining Hsp90’s inherent ATPase activity

Christopher Avila, Boris A. Kornilayev, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 215 KB

english, 2006

20

Erratum to: Novel C-terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents

Stephanie M. Cohen, Ridhwi Mukerji, Abbas K. Samadi, Xuan Zhang, Huiping Zhao, Brian S. J. Blagg, Mark S. Cohen

Journal:

Annals of Surgical Oncology

Year:

2012

File:

PDF, 106 KB

2012

21

Targeting the Heat Shock Protein 90 Dimer with Dimeric Inhibitors

Kusuma, Bhaskar Reddy, Peterson, Laura B., Zhao, Huiping, Vielhauer, George, Holzbeierlein, Jeffrey, Blagg, Brian S. J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.17 MB

english, 2011

22

The hERG Channel Is Dependent upon the Hsp90α Isoform for Maturation and Trafficking

Peterson, Laura B., Eskew, Jeffrey D., Vielhauer, George A., Blagg, Brian S. J.

Journal:

Molecular Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 3.14 MB

english, 2012

23

Chaperone substrate provides missing link for cancer drug discovery

Byrd, Katherine M., Blagg, Brian S. J.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 302 KB

english, 2018

24

Synthesis of (-)-Noviose from 2,3-O-Isopropylidene-D-erythronolactol.

Xiao Ming Yu, Gang Shen, Brian S. J. Blagg

Journal:

Year:

2005

File:

PDF, 9 KB

2005

25

ChemInform Abstract: Indentification and Initial SAR of Silybin: An Hsp90 Inhibitor.

Huiping Zhao, Gary E. Brandt, Lakshmi Galam, Robert L. Matts, Brian S. J. Blagg

Journal:

Year:

2012

File:

PDF, 29 KB

2012

26

3-Arylcoumarin Derivatives Manifest Anti-proliferative Activity through Hsp90 Inhibition

Zhao, Huiping, Yan, Bin, Peterson, Laura B., Blagg, Brian S. J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

27

Synthesis of Cruentaren A

Kusuma, Bhaskar Reddy, Brandt, Gary E. L., Blagg, Brian S. J.

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 506 KB

english, 2012

28

Cruentaren A Binds F 1 F 0 ATP Synthase To Modulate the Hsp90 Protein Folding Machinery

Hall, Jessica A., Kusuma, Bhaskar Reddy, Brandt, Gary E. L., Blagg, Brian S. J.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.47 MB

english, 2014

29

Cytotoxic sugar analogues of an optimized novobiocin scaffold

Donnelly, Alison C., Zhao, Huiping, Reddy Kusuma, Bhaskar, Blagg, Brian S. J.

Journal:

Year:

2010

Language:

english

File:

PDF, 260 KB

english, 2010

30

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

Dunn, Diana M., Woodford, Mark R., Truman, Andrew W., Jensen, Sandra M., Schulman, Jacqualyn, Caza, Tiffany, Remillard, Taylor C., Loiselle, David, Wolfgeher, Donald, Blagg, Brian S.J., Franco, Lucas,

Journal:

Year:

2015

Language:

english

File:

PDF, 2.59 MB

english, 2015

31

Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects

Forsberg, Leah K., Anyika, Mercy, You, Zhenyuan, Emery, Sean, McMullen, Mason, Dobrowsky, Rick T., Blagg, Brian S.J.

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.17 MB

english, 2017

32

Cover Feature: Synthesis and Biological Evaluation of Stilbene Analogues as Hsp90 C-Terminal Inhibitors (ChemMedChem 24/2017)

Byrd, Katherine M., Kent, Caitlin N., Blagg, Brian S. J.

Journal:

Year:

2017

File:

PDF, 835 KB

2017

33

Intramolecular Diels—Alder and Tandem Intramolecular Diels—Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles.

Gordon D. Wilkie, Gregory I. Elliott, Brian S. J. Blagg, Scott E. Wolkenberg, Danielle R. Soenen, Michael M. Miller, Scott Pollack, Dale L. Boger

Journal:

Year:

2003

File:

PDF, 243 KB

2003

34

486 DEVELOPMENT OF A HIGH-THROUGHPUT SCREENING ASSAY FOR THE IDENTIFICATION OF CANCER CELL-SPECIFIC HSP90

Woodruff, Daniel, Sadikot, Takrima, Eskew, Jeff, Blagg, Brian, Vielhauer, George, Holzbeierlein, Jeffrey

Journal:

The Journal of Urology

Year:

2012

Language:

english

File:

PDF, 50 KB

english, 2012

35

Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity Relationships

Brandt, Gary E. L., Schmidt, Matthew D., Prisinzano, Thomas E., Blagg, Brian S. J.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 303 KB

english, 2008

36

Development of radamide analogs as Grp94 inhibitors

Muth, Aaron, Crowley, Vincent, Khandelwal, Anuj, Mishra, Sanket, Zhao, Jinbo, Hall, Jessica, Blagg, Brian S.J.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.90 MB

english, 2014

37

Synthesis of 2- C -Methyl- d -erythritol 4-Phosphate: The First Pathway-Specific Intermediate in the Methylerythritol Phosphate Route to Isoprenoids

Koppisch, Andrew T., Blagg, Brian S. J., Poulter, C. Dale

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 34 KB

english, 2000

38

C-Terminal Heat Shock Protein 90 Inhibitor Decreases Hyperglycemia-induced Oxidative Stress and Improves Mitochondrial Bioenergetics in Sensory Neurons

Zhang, Liang, Zhao, Huiping, Blagg, Brian S. J., Dobrowsky, Rick T.

Journal:

Journal of Proteome Research

Year:

2012

Language:

english

File:

PDF, 4.62 MB

english, 2012

39

Synthesis and Evaluation of Derrubone and Select Analogues

Hastings, Jedidiah M., Hadden, M. Kyle, Blagg, Brian S. J.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 173 KB

english, 2008

40

KU-32, a Novel Drug for Diabetic Neuropathy, Is Safe for Human Islets and Improves In Vitro Insulin Secretion and Viability

Farmer, Kevin, Williams, S. Janette, Novikova, Lesya, Ramachandran, Karthik, Rawal, Sonia, Blagg, Brian S. J., Dobrowsky, Rick, Stehno-Bittel, Lisa

Journal:

Experimental Diabetes Research

Year:

2012

Language:

english

File:

PDF, 2.26 MB

english, 2012

41

Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors

forsberg, leah, garg, gaurav, zhao, huiping, Blagg, Brian

Journal:

Chemistry - A European Journal

Year:

2017

Language:

english

File:

PDF, 2.60 MB

english, 2017

42

A scaffold merging approach to Hsp90 C-terminal inhibition: synthesis and evaluation of a chimeric library

Davis, Rachel E., Zhang, Zheng, Blagg, Brian S. J.

Journal:

Year:

2017

Language:

english

File:

PDF, 898 KB

english, 2017

43

Synthesis of 1-Deoxy-d-xylulose and 1-Deoxy-d-xylulose-5-phosphate

Blagg, Brian S. J., Poulter, C. Dale

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

44

Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles

Elliott, Gregory I., Fuchs, James R., Blagg, Brian S. J., Ishikawa, Hayato, Tao, Houchao, Yuan, Z.-Q., Boger, Dale L.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 302 KB

english, 2006

45

Derrubone, an Inhibitor of the Hsp90 Protein Folding Machinery

Hadden, M. Kyle, Galam, Lakshmi, Gestwicki, Jason E., Matts, Robert L., Blagg, Brian S. J.

Journal:

Journal of Natural Products

Year:

2007

Language:

english

File:

PDF, 366 KB

english, 2007

46

Modified Biphenyl Hsp90 C-terminal Inhibitors for the Treatment of Cancer

Forsberg, Leah K., Liu, Weiya, Holzbeierlein, Jeffrey, Blagg, Brian S.J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 827 KB

english, 2017

47

Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors

Vinod D. Jadhav, Adam S. Duerfeldt, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 635 KB

english, 2009

48

Synthesis and Evaluation of Coumermycin A1 Analogues that Inhibit the Hsp90 Protein Folding Machinery

Burlison, Joseph A., Blagg, Brian S. J.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 123 KB

english, 2006

49

Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors

Bhaskar Reddy Kusuma, Adam S. Duerfeldt, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 805 KB

english, 2011

50

A Versatile Approach toward the Ansamycin Antibiotics

Peng, Weimin, Blagg, Brian S. J.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 322 KB

english, 2006

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